Removal of Residual Palladium

Potassium isopropyl xanthate (PIX) is an ultra-efficient palladium scavenger, the latest and Efficient Method for Removal of Residual Palladium from Organic solvents.

The increasing employment of palladium-catalysed reactions in the synthesis of active pharmaceutical ingredients (APIs) has created a pressing need for ultra-efficient palladium removal of the resulting metal contaminants.
The identification and development of Potassium Isopropyl Xanthate (PIX) as a simple, readily available and ultra-efficient palladium scavenger has the ability to remove residual palladium from the API to levels less than 1 ppm. In addition, the discovery of a synergistic effect of iodine, in combination with PIX and other palladium scavengers, to enhance palladium removal has further increased the efficiency of the palladium removal process. The PIX and I2 system has been successfully applied to the ceftolozane sulfate 2nd generation manufacturing chemistry to reduce palladium in the API resulting from a late stage palladium-catalysed coupling reaction to only 0.1 ppm. Active pharmaceutical ingredients, heavy-metal impurities, homogeneous catalysis, and purification are the important points in separation science for which the advance technologies have to be developed. 

  • Palladium scavenger
  • Residual Palladium removal method
  • Heavy-metal impurities
  • Potassium isopropyl as a palladium scavenger

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